Disclaimer
Products supplied by SYNA Labs Ltd are intended strictly for laboratory and scientific research purposes only. They are not medicines, are not approved for human or veterinary use, and must not be used to diagnose, treat, cure, or prevent any disease or medical condition. Products are not for human or animal consumption, cosmetic, food, or recreational use. By purchasing from SYNA Labs Ltd, customers confirm they are qualified individuals or entities purchasing solely for legitimate research purposes and agree to our Terms and Conditions and Research Use Policy.
Copper is an essential trace element required for numerous enzymatic and structural proteins involved in redox balance, extracellular matrix organisation, and cellular metabolism. By acting as a carrier and regulator of bioavailable copper, GHK-Cu plays a role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling.
In preclinical research models, exposure to GHK-Cu has been associated with altered gene expression patterns and modulation of signalling pathways related to extracellular matrix dynamics, oxidative stress response, and cellular turnover. These effects are context-dependent and vary with concentration, exposure duration, and experimental system, making GHK-Cu a widely used molecular tool for investigating copper-mediated signalling and peptide–metal interactions in vitro and in vivo.
Product: GHK-Cu
Synonyms / Designations: GHK-Cu, Copper Tripeptide-1, Glycyl-L-histidyl-L-lysine copper complex
CAS Number: 49557-75-7
Molecular Formula: C14H24CuN6O4
Molecular Weight: 403.92 g/mol
Purity: ≥ 99 % (HPLC)
Appearance: Blue to deep blue lyophilised powder
Pack Size: 50 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Water and buffered aqueous solutions; limited solubility in organic solvents.
Applications in Research
- As a molecular probe to study copper transport, binding, and homeostasis in biological systems.
- To investigate copper-dependent signalling pathways involved in cellular growth, differentiation, and tissue remodelling.
- In cell-based assays examining changes in gene expression, redox-sensitive signalling, and extracellular matrix regulation.
- In animal or ex vivo experimental models for mechanistic investigation of peptide–metal interactions, copper bioavailability, and metal-mediated tissue signalling processes.
Specifications Summary
| Parameter | Typical Value / Range |
| Purity (HPLC) | ≥ 99 |
| Appearance | Blue to deep blue lyophilised powder |
| Molecular Weight | 403.92 g/mol |
| Compound Type | Copper-binding tripeptide |
| Solubility | Water, dilute acids, DMSO |
| Storage | –20 °C, desiccated, dark |
| Pack Size | 50mg |
Handling, Reconstitution & Stability
- Weigh under inert/dry conditions; avoid moisture uptake.
- Avoid metal-chelating agents (e.g. EDTA) or buffers that may disrupt copper coordination.
- For stock solutions, dissolve in sterile water or appropriate buffered aqueous solution depending on assay requirements.
- Filter sterilize if needed (e.g. 0.22 µm) immediately prior to use.
- Aliquot and store stock solutions at –20 °C (or lower) to avoid repeated freeze–thaw.
- Monitor for precipitation or pH shifts before use in sensitive assays.
Precautions & Notes
- GHK-Cu activity is concentration-dependent; perform appropriate dose–response controls.
- Copper coordination may be affected by pH, ionic strength, and chelating agents.
- Light exposure and prolonged aqueous storage may reduce stability.
- Intended strictly for laboratory research use; not for human or veterinary application.
